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Dogs With This Mutation May Develop Signs Of Severe Avermectin Toxicity If They Ingest This Product. It contains doramectin, a novel fermentation-derived avermectin discovered by Pfizer. The chemical composition of selamectin is (5Z, 25S) - 25 - cyclohexyl - 4' - O - de(2,6 - dideoxy - 3 - O - methyl - α - L - arabino - hexopyranosyl) - 5 - demethoxy - 25 - de(1 - methylpropyl) - 22, 23-dihydro-5-hydroxyiminoavermectin A1a. , pyrethroids, organophosphates, chlorinated hydrocarbons or avermectin) may lead to the development of resistance to that class of insecticide. Ivermectin is a mixture containing at least 90% 5-O-demethyl-22,23-dihydroavermectin A1a and less than 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a, generally referred to as 22,23-dihydroavermectin B1a and B1b, or H2B1a and H2B1b, respectively. The avermectins are highly active, broad-spectrum antiparasitic agents isolated from fermentation of the soil organism Streptomyces avermitilis. In mammals, the neuronal receptors to which avermectins bind are localized within the central nervous system (CNS), a site reached by only negligible concentrations of doramectin. Ivermectin is derived from the avermectins, a class of highly active broad-spectrum, anti-parasitic agents isolated from the fermentation products of Streptomyces avermitilis. Discovered and developed by scientists from Merck Research Laboratories, IVOMEC EPRINEX Pour-On contains eprinomectin, a unique avermectin. In a topical safety study conducted with avermectin-sensitive collies at 1, 3 and 5 times the recommended dose of Revolution, salivation was observed in all treatment groups, including the vehicle control. 5, 10, and 15 mg/kg in this dose escalating study did not cause any adverse reactions; however, eight hours after receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not show any other adverse reactions after receiving subsequent doses of 10 and 15 mg/kg orally. Its action is unique to the avermectin class of antiparasitic agents. At 40% of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized. It contains doramectin, a novel fermentation-derived avermectin discovered by Pfizer Inc. Avermectins bind to receptors that increase membrane permeability to chloride ions.



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